Dr. Domchek on the MEDIOLA Trial in Breast Cancer

Susan Domchek, MD
Published: Tuesday, Dec 19, 2017



Susan Domchek, MD, director of the Basser Center for BRCA at Penn Medicine, discusses the MEDIOLA trial in breast cancer.

During the 2017 San Antonio Breast Cancer Symposium, the results of the first 25 patients with BRCA1/2-mutated metastatic breast cancer treated with olaparib (Lynparza) and durvalumab (Imfinzi) from the MEDIOLA trial were presented.

Results showed an 80% clinical benefit rate at 12 weeks, suggesting that this is an active combination in this population. The impact of durvalumab is still unknown, says Domchek, as olaparib has shown benefit as a single-agent in this population.


Susan Domchek, MD, director of the Basser Center for BRCA at Penn Medicine, discusses the MEDIOLA trial in breast cancer.

During the 2017 San Antonio Breast Cancer Symposium, the results of the first 25 patients with BRCA1/2-mutated metastatic breast cancer treated with olaparib (Lynparza) and durvalumab (Imfinzi) from the MEDIOLA trial were presented.

Results showed an 80% clinical benefit rate at 12 weeks, suggesting that this is an active combination in this population. The impact of durvalumab is still unknown, says Domchek, as olaparib has shown benefit as a single-agent in this population.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Cancer Summaries and Commentaries™: Update from Chicago: Advances in the Treatment of Breast CancerJul 31, 20181.0
Community Practice Connections™: Medical Crossfire®: Translating Lessons Learned with PARP Inhibition to the Treatment of Breast Cancer—Expert Exchanges on Novel Strategies to Personalize CareAug 29, 20181.5
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