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Dr. Domchek on the MEDIOLA Trial in Breast Cancer

Susan Domchek, MD
Published: Tuesday, Dec 19, 2017



Susan Domchek, MD, director of the Basser Center for BRCA at Penn Medicine, discusses the MEDIOLA trial in breast cancer.

During the 2017 San Antonio Breast Cancer Symposium, the results of the first 25 patients with BRCA1/2-mutated metastatic breast cancer treated with olaparib (Lynparza) and durvalumab (Imfinzi) from the MEDIOLA trial were presented.

Results showed an 80% clinical benefit rate at 12 weeks, suggesting that this is an active combination in this population. The impact of durvalumab is still unknown, says Domchek, as olaparib has shown benefit as a single-agent in this population.


Susan Domchek, MD, director of the Basser Center for BRCA at Penn Medicine, discusses the MEDIOLA trial in breast cancer.

During the 2017 San Antonio Breast Cancer Symposium, the results of the first 25 patients with BRCA1/2-mutated metastatic breast cancer treated with olaparib (Lynparza) and durvalumab (Imfinzi) from the MEDIOLA trial were presented.

Results showed an 80% clinical benefit rate at 12 weeks, suggesting that this is an active combination in this population. The impact of durvalumab is still unknown, says Domchek, as olaparib has shown benefit as a single-agent in this population.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Community Practice Connections: Oncology Best Practice™ Targeting Cell Cycle Progression: The Latest Advances on CDK4/6 Inhibition in Metastatic Breast CancerOct 31, 20181.0
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