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Dr. Fakih on Angiogenesis Versus EGFR Inhibitors in CRC

Marwan G. Fakih, MD
Published: Tuesday, Feb 25, 2014

Marwan G. Fakih, MD, professor, director, Gastrointestinal Medical Oncology, City of Hope, discusses anti-angiogenesis versus anti-EGFR therapy in patients who have RAS wild-type colorectal cancer.

Fakih says it is important for researchers to figure out which therapy is more beneficial for patients who have RAS wild-type colorectal cancer in the first-line setting. There are hints that anti-EGFR therapy is effective in the first-line setting based on the FIRE-3 data, Fakih says, but it is important to see the results of C80405. Especially since the FIRE-3 data shows a lack of improvement in patient’s progression-free survival.

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Marwan G. Fakih, MD, professor, director, Gastrointestinal Medical Oncology, City of Hope, discusses anti-angiogenesis versus anti-EGFR therapy in patients who have RAS wild-type colorectal cancer.

Fakih says it is important for researchers to figure out which therapy is more beneficial for patients who have RAS wild-type colorectal cancer in the first-line setting. There are hints that anti-EGFR therapy is effective in the first-line setting based on the FIRE-3 data, Fakih says, but it is important to see the results of C80405. Especially since the FIRE-3 data shows a lack of improvement in patient’s progression-free survival.

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