Dr. Gangadhar on Combination Regimens for Melanoma

Tara C. Mitchell, MD
Published: Monday, Feb 13, 2017



Tara C. Mitchell, MD, assistant professor of Medicine, Perelman School of Medicine at the Hospital of the University of Pennsylvania, discusses new combination regimens for patients with melanoma.

The combination of the oncolytic immunotherapy talimogene laherparepvec (T-VEC) combined with pembrolizumab (Keytruda) was shown to be safe and effective in a small phase I study, Gangadhar explains. It is now accruing patients with advanced melanoma in a randomized phase III study.

IDO inhibition with the oral inhibitor epacadostat in combination with pembrolizumab also showed excellent efficacy in a small early-phase study of melanoma with no evidence of added toxicity, Gangadhar adds.

Combining immunotherapy with a targeted therapy, such as with a PD-L1 blockade with atezolizumab (Tecentriq) with vemurafenib (Zelboraf) and cobimetinib (Cotellic), have preliminary results of safety and efficacy.
 


Tara C. Mitchell, MD, assistant professor of Medicine, Perelman School of Medicine at the Hospital of the University of Pennsylvania, discusses new combination regimens for patients with melanoma.

The combination of the oncolytic immunotherapy talimogene laherparepvec (T-VEC) combined with pembrolizumab (Keytruda) was shown to be safe and effective in a small phase I study, Gangadhar explains. It is now accruing patients with advanced melanoma in a randomized phase III study.

IDO inhibition with the oral inhibitor epacadostat in combination with pembrolizumab also showed excellent efficacy in a small early-phase study of melanoma with no evidence of added toxicity, Gangadhar adds.

Combining immunotherapy with a targeted therapy, such as with a PD-L1 blockade with atezolizumab (Tecentriq) with vemurafenib (Zelboraf) and cobimetinib (Cotellic), have preliminary results of safety and efficacy.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Medical Crossfire®: Evolving Roles for Targeted Melanoma Therapies: Assessing Rapid Progress in the Field and Looking Toward Future CombinationsFeb 28, 20191.5
Community Practice Connections™: New Directions in Advanced Cutaneous Squamous Cell Carcinoma: Emerging Evidence of ImmunotherapyAug 13, 20191.5
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