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Dr. Gettinger on Lung Cancer Immunotherapies

Scott Gettinger, MD
Published: Tuesday, Jan 08, 2013

Scott Gettinger, MD, associate professor of medicine (medical oncology), Yale School of Medicine, explains the development of immunotherapies in lung cancer.

Gettinger says that though there has not been a consistent advantage to immunotherapies to this point, it may change soon. Certain immune checkpoints have been identified, which suppresses the immune system and prevent against autoimmunity. In cancer, this suppression of the immune system allows tumors to attack and spread in the body.

Immunotherapies such as anti-PD-1 and ipilimumab prevent the “brakes” on the immune system and allow T-cells to help fight the cancer, Gettinger says. Future trials in lung cancer may examine the combination of several immunotherapies, including the reexamination of older therapies.

Scott Gettinger, MD, associate professor of medicine (medical oncology), Yale School of Medicine, explains the development of immunotherapies in lung cancer.

Gettinger says that though there has not been a consistent advantage to immunotherapies to this point, it may change soon. Certain immune checkpoints have been identified, which suppresses the immune system and prevent against autoimmunity. In cancer, this suppression of the immune system allows tumors to attack and spread in the body.

Immunotherapies such as anti-PD-1 and ipilimumab prevent the “brakes” on the immune system and allow T-cells to help fight the cancer, Gettinger says. Future trials in lung cancer may examine the combination of several immunotherapies, including the reexamination of older therapies.




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Oncology Briefings™: Updates in Novel Therapeutic Options for Lung Neuroendocrine TumorsMay 31, 20181.0
Community Practice Connections™: Working Group to Optimize Outcomes in EGFR-mutated Lung Cancers: Evolving Concepts for Nurses to Facilitate and Improve Patient CareJun 30, 20181.5
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