Dr. Gordon on the Role of Checkpoint Inhibitors in Hematologic Malignancies

Leo I. Gordon, MD
Published: Monday, Nov 20, 2017



Leo I. Gordon, MD, professor of medicine, Feinberg School of Medicine, Northwestern University, discusses the role of checkpoint inhibitors for patients with hematologic malignancies.

According to Gordon, there was an international trial of 72 patients who received pidilizumab (CT-011), which is one of the first checkpoint inhibitors. It may not work as a checkpoint inhibitor, but there was very little toxicity associated with the drug.

The PLATFORM study is going to be combining the checkpoint inhibitor durvalumab (Imfinzi) with CAR T cells in patients with diffuse large B-cell lymphoma (DLBCL). It makes sense to combine the checkpoint inhibitors with CAR T cells; however, the safety issues, the dosing, and the sequencing still need to be determined, states Gordon.
 
SELECTED
LANGUAGE


Leo I. Gordon, MD, professor of medicine, Feinberg School of Medicine, Northwestern University, discusses the role of checkpoint inhibitors for patients with hematologic malignancies.

According to Gordon, there was an international trial of 72 patients who received pidilizumab (CT-011), which is one of the first checkpoint inhibitors. It may not work as a checkpoint inhibitor, but there was very little toxicity associated with the drug.

The PLATFORM study is going to be combining the checkpoint inhibitor durvalumab (Imfinzi) with CAR T cells in patients with diffuse large B-cell lymphoma (DLBCL). It makes sense to combine the checkpoint inhibitors with CAR T cells; however, the safety issues, the dosing, and the sequencing still need to be determined, states Gordon.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Cancer Summaries and Commentaries™: Update from Atlanta: Advances in the Treatment of Chronic Lymphocytic LeukemiaFeb 28, 20190.5
Medical Crossfire®: Evolving Roles for Targeted Melanoma Therapies: Assessing Rapid Progress in the Field and Looking Toward Future CombinationsFeb 28, 20191.5
Publication Bottom Border
Border Publication
x