Dr. Gulley on the Adverse Event Profile for PROSTVAC

James L. Gulley, MD, PhD
Published: Thursday, Jun 27, 2013

James L. Gulley, MD, PhD, Head, Clinical Trials Group, Deputy Laboratory Chief, National Cancer Institute (NCI), gives an overview of the adverse event profile for PROSTVAC.

PROSTVAC is an immunotherapeutic vaccine for men with castration-resistant prostate cancer. The adverse event profile for PROSTVAC was just updated for all trials by the NCI, Gulley says. The analysis found that the majority of patients experienced few side effects.

The most common side effect was an injection site reaction: redness or a bump where the injection was given. This type of side effect is clinically insignificant, Gulley says. Some patients, about 5-10%, experienced mild to moderate flu-like symptoms, which is indicative of a strong immune response.

James L. Gulley, MD, PhD, Head, Clinical Trials Group, Deputy Laboratory Chief, National Cancer Institute (NCI), gives an overview of the adverse event profile for PROSTVAC.

PROSTVAC is an immunotherapeutic vaccine for men with castration-resistant prostate cancer. The adverse event profile for PROSTVAC was just updated for all trials by the NCI, Gulley says. The analysis found that the majority of patients experienced few side effects.

The most common side effect was an injection site reaction: redness or a bump where the injection was given. This type of side effect is clinically insignificant, Gulley says. Some patients, about 5-10%, experienced mild to moderate flu-like symptoms, which is indicative of a strong immune response.


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
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