Dr. Guminski on 16-Month Follow-Up With Cemiplimab in mCSCC

Video

Alexander Guminski, MD, PhD, medical oncologist, Royal North Shore Hospital, University of Sydney, discusses the 16-month follow-up results of a phase II trial evaluating cemiplimab (Libtayo) in patients with metastatic cutaneous squamous cell carcinoma.

Alexander Guminski, MD, PhD, medical oncologist, Royal North Shore Hospital, University of Sydney, discusses the 16-month follow-up results of a phase II trial evaluating cemiplimab (Libtayo) in patients with metastatic cutaneous squamous cell carcinoma.

In a primary analysis reported in October 2017, cemiplimab, a human monoclonal anti-PD-1 agent, demonstrated significant antitumor activity, response rates, and promising safety. In the trial, 59 patients were given 3 mg/kg of cemiplimab intravenously every 2 weeks. Tumors were measured every 8 weeks to evaluate overall response rate (ORR), which served as the primary endpoint of the trial. More than half the patients had one or more prior lines of systemic treatment, while three-fourths of patients had distant visceral metastatic disease.

At a median follow-up of 16 months, Guminski reports that there was slight improvement in ORR as the data has matured. Specifically, an ORR of 49% was reported, with 17% of that group achieving a complete response to the treatment.

Related Videos
Ricardo D. Parrondo, MD, hematologist/oncologist, Mayo Clinic
Ilyas Sahin, MD
Raj Singh, MD
Jaime R. Merchán, MD, professor, co-leader, Translational and Clinical Oncology Research Program, director, Phase 1 Clinical Trials Program, Department of Medicine, Division of Medical Oncology, the University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center
Saad J. Kenderian, MB, CHB
Tycel Phillips, MD
Minesh Mehta, MD
Shivaani Kummar, MBBS, FACP, Margaret and Lester DeArmond Endowed Chair of Cancer Research, Professor and Division Head, Division of Hematology/Medical Oncology, Oregon Health & Science University School of Medicine; co-director, Center for Experimental Therapeutics, co-deputy director, Knight Cancer Institute
Andre Goy, MD
Wenxin (Vincent) Xu, MD,