Dr. Janjigian Discusses Afatinib and Cetuximab for Patients With EGFR-Mutant Lung Cancer

Yelena Y. Janjigian, MD
Published: Monday, Aug 04, 2014

Yelena Y. Janjigian, MD, assistant attending physician, Memorial Sloan Kettering Cancer Center, discusses results of an early-phase study looking at afatinib and cetuximab for patients with EGFR-mutant lung cancer.

This trial showed dramatic and durable responses in tumor shrinkage in patients with acquired resistant to erlotinib or gefitinib. Of those patients treated at the maximum tolerated dose, 29% experienced tumor regression — a substantial proportion of this group had tumor regression of greater than 50%, which typically translates to improvement in symptoms and quality of life.

Janjigian says that afatinib and cetuximab have overlapping toxicity profiles and that patients in this trial experienced diarrhea and rash.

Read more about this study > >

Yelena Y. Janjigian, MD, assistant attending physician, Memorial Sloan Kettering Cancer Center, discusses results of an early-phase study looking at afatinib and cetuximab for patients with EGFR-mutant lung cancer.

This trial showed dramatic and durable responses in tumor shrinkage in patients with acquired resistant to erlotinib or gefitinib. Of those patients treated at the maximum tolerated dose, 29% experienced tumor regression — a substantial proportion of this group had tumor regression of greater than 50%, which typically translates to improvement in symptoms and quality of life.

Janjigian says that afatinib and cetuximab have overlapping toxicity profiles and that patients in this trial experienced diarrhea and rash.

Read more about this study > >


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 18th Annual International Lung Cancer Congress®Oct 31, 20181.5
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Publication Bottom Border
Border Publication
x