Dr. Mannis Talks About Emerging Treatments for Acute Myeloid Leukemia

Gabriel Mannis, MD
Published: Thursday, Jan 18, 2018



Gabriel Mannis, MD, assistant professor, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, discusses new methods of treatment for acute myeloid leukemia (AML).

In the last 6 to 9 months, 4 new drugs have been approved by the FDA. CPX-351 (Vyxeos) was approved as a liposomal version of 7+3 chemotherapy, which combines cytarabine and daunorubicin in a 5:1 molar ratio. In patients with secondary AML, therapy-related AML, or de novo AML with myelodysplasia-related changes, the drug was shown to improve overall survival (OS). OS almost doubled for patients receiving CPX-351 relative to 7+3 chemotherapy.

For patients with secondary AML or therapy-related AML, CPX-351 is the new standard of care for fit patients who are able to undergo intensive chemotherapy. Opposed to traditional chemotherapy agents, patients do not lose their hair as it is much less toxic than standard 7+3 chemotherapy.
 
SELECTED
LANGUAGE


Gabriel Mannis, MD, assistant professor, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, discusses new methods of treatment for acute myeloid leukemia (AML).

In the last 6 to 9 months, 4 new drugs have been approved by the FDA. CPX-351 (Vyxeos) was approved as a liposomal version of 7+3 chemotherapy, which combines cytarabine and daunorubicin in a 5:1 molar ratio. In patients with secondary AML, therapy-related AML, or de novo AML with myelodysplasia-related changes, the drug was shown to improve overall survival (OS). OS almost doubled for patients receiving CPX-351 relative to 7+3 chemotherapy.

For patients with secondary AML or therapy-related AML, CPX-351 is the new standard of care for fit patients who are able to undergo intensive chemotherapy. Opposed to traditional chemotherapy agents, patients do not lose their hair as it is much less toxic than standard 7+3 chemotherapy.
 



View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Addressing Post-Transplant Obstacles: Current and Emerging Strategies to Evolve the Standard of Care for Patients With Graft-Versus-Host DiseaseMar 28, 20192.0
2017 Year in Review™: Clinical Impact of Immunotherapies in the Treatment of CancerMar 30, 20191.75
Publication Bottom Border
Border Publication
x