Dr. Petrylak on Custirsen in Prostate Cancer

Daniel P. Petrylak, MD
Published: Monday, Mar 24, 2014

Daniel P. Petrylak, MD, director, Prostate and GU Medical Oncology, Yale Cancer Center, discusses a phase III trial measuring the efficacy of custirsen plus docetaxel versus docetaxel alone in patients with prostate cancer (SYNERGY trial).

Petrylak believes the science behind custirsen is good. Custirsen is a second-generation antisense inhibitor of clusterin​​, which may play a fundamental role in cancer cell survival and treatment resistance.

In a phase II trial, prostate cancer patients experienced a survival benefit when treated with custirsen. The results of the phase III trial should read out this year, Petrylak says.

Daniel P. Petrylak, MD, director, Prostate and GU Medical Oncology, Yale Cancer Center, discusses a phase III trial measuring the efficacy of custirsen plus docetaxel versus docetaxel alone in patients with prostate cancer (SYNERGY trial).

Petrylak believes the science behind custirsen is good. Custirsen is a second-generation antisense inhibitor of clusterin​​, which may play a fundamental role in cancer cell survival and treatment resistance.

In a phase II trial, prostate cancer patients experienced a survival benefit when treated with custirsen. The results of the phase III trial should read out this year, Petrylak says.


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Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
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