Dr. Petrylak on Enzalutamide's Role in Prostate Cancer

Daniel P. Petrylak, MD
Published: Tuesday, Oct 09, 2012

Daniel P. Petrylak, MD, director, Prostate and Genitourinary Cancer Program, co-director, Signal Transduction Research Program, at the Smilow Cancer Center at Yale-New Haven, discusses his excitement over the recent approval of enzalutamide (Xtandi) for patients with metastatic castration-resistant prostate cancer (mCRPC) who have been previously treated with docetaxel and hormonal therapy.

Petrylak believes the approval of enzalutamide validates the theory that further manipulation of the hormone axis leads to improved outcomes. In addition to the recent approval, enzalutamide is currently being investigated earlier in the treatment process, similarly to abiraterone acetate (Zytiga).

One of the advantages of enzalutamide is that it can be given without the co-administration of a corticosteroid, Petrylak explains. This is beneficial because the immunotherapy sipuleucel-T (Provenge) requires at least one month following corticosteroid administration before the leukapheresis process can begin. Removing this added wait time will improve outcomes for patients, Petrylak believes.

Daniel P. Petrylak, MD, director, Prostate and Genitourinary Cancer Program, co-director, Signal Transduction Research Program, at the Smilow Cancer Center at Yale-New Haven, discusses his excitement over the recent approval of enzalutamide (Xtandi) for patients with metastatic castration-resistant prostate cancer (mCRPC) who have been previously treated with docetaxel and hormonal therapy.

Petrylak believes the approval of enzalutamide validates the theory that further manipulation of the hormone axis leads to improved outcomes. In addition to the recent approval, enzalutamide is currently being investigated earlier in the treatment process, similarly to abiraterone acetate (Zytiga).

One of the advantages of enzalutamide is that it can be given without the co-administration of a corticosteroid, Petrylak explains. This is beneficial because the immunotherapy sipuleucel-T (Provenge) requires at least one month following corticosteroid administration before the leukapheresis process can begin. Removing this added wait time will improve outcomes for patients, Petrylak believes.


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
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