Dr. Ramalingam on Hsp90 Inhibition With Ganetespib

Suresh S. Ramalingam, MD
Published: Thursday, Jul 18, 2013

Suresh S. Ramalingam, MD, a professor of medical oncology at the Winship Cancer Institute of Emory University in Atlanta, Georgia, discusses the role of heat shock proteins in normal cells and their potential role in treating cancer.

Heat shock proteins are often labeled chaperones because newly formed proteins require their assistance to become structurally active and perform their biologic function, Ramalingam notes. However, blocking this process by the inhibition of heat shock protein (Hsp) 90 with an agent like ganetespib renders these new proteins inactive.

In lung cancer, proteins such as EGFR and ALK, which stimulate tumor growth, depend on Hsp90 for activation. Altogether, Ramalingam notes, there are over 200 known proteins associated with Hsp90, many of which are important to the development of lung cancer. The promise with ganetespib is that by inhibiting Hsp90, multiple oncoproteins that fuel lung cancer would be inhibited at the same time.

Suresh S. Ramalingam, MD, a professor of medical oncology at the Winship Cancer Institute of Emory University in Atlanta, Georgia, discusses the role of heat shock proteins in normal cells and their potential role in treating cancer.

Heat shock proteins are often labeled chaperones because newly formed proteins require their assistance to become structurally active and perform their biologic function, Ramalingam notes. However, blocking this process by the inhibition of heat shock protein (Hsp) 90 with an agent like ganetespib renders these new proteins inactive.

In lung cancer, proteins such as EGFR and ALK, which stimulate tumor growth, depend on Hsp90 for activation. Altogether, Ramalingam notes, there are over 200 known proteins associated with Hsp90, many of which are important to the development of lung cancer. The promise with ganetespib is that by inhibiting Hsp90, multiple oncoproteins that fuel lung cancer would be inhibited at the same time.




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 18th Annual International Lung Cancer Congress®Oct 31, 20181.5
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Publication Bottom Border
Border Publication
x