Dr. Ring on Molecular Profiling of CTCs in Advanced Breast Cancer

Video

Alexander Ring, MD, graduate student, University of Southern California, discusses a study investigating the molecular profiling of circulating tumor cells (CTCs) as a surrogate for distant metastasis in patients with stage IV breast cancer.

Alexander Ring, MD, graduate student, University of Southern California, discusses a study investigating the molecular profiling of circulating tumor cells (CTCs) as a surrogate for distant metastasis in patients with stage IV breast cancer.

CTC samples from 8 patients with metastatic breast cancer were obtained, as well as peripheral blood samples and metastatic biopsies. All samples underwent RNA sequencing from genomic profiling and were analyzed to determine if the CTCs can serve as a surrogate for biopsies, Ring explains.

Results showed that gene expression signatures correlate with distant macrometastatic sites. Additionally, the gene-expression patterns revealed biological information that could be used as biomarkers or identify potential therapeutic targets.

Related Videos
Shivaani Kummar, MBBS, FACP, Margaret and Lester DeArmond Endowed Chair of Cancer Research, Professor and Division Head, Division of Hematology/Medical Oncology, Oregon Health & Science University School of Medicine; co-director, Center for Experimental Therapeutics, co-deputy director, Knight Cancer Institute
Andre Goy, MD
Wenxin (Vincent) Xu, MD,
Guenther Koehne, MD, PhD
Alessandro Villa, DDS, PhD, MPH
Joseph Mikhael, MD
Michael Richardson, MD
Video 1 - "HR+/HER2- Early-Stage Breast Cancer: Background and Risk Stratification "
Minesh Mehta, MD
Ruben Olivares, MD