Dr. Rugo on Chemotherapy for Metastatic Breast Cancer

Hope S. Rugo, MD
Published: Tuesday, May 28, 2013

Hope S. Rugo, MD, professor of medicine and director of breast oncology and clinical trials education at the University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, discusses the treatment of patients with metastatic breast cancer with chemotherapy.

Treating a patient with metastatic breast cancer with chemotherapy is controversial for a number of reasons, Rugo says. Several factors come into consideration in this setting: the choice of combination or single therapy, sequencing, treatment schedule, and length of treatment.

There is data that shows a better outcome for patients who continue on chemotherapy after response compared with those who go on a chemotherapy holiday. The caveat of this data is that many patients had hormone receptor-positive disease but did not receive hormone therapy during the chemotherapy holiday. The standard in the U.S. is to treat this group of patients with hormone therapy during a break.

For patients with triple-negative hormone-resistant disease, continued therapy was better for outcome than stopping and restarting.

Hope S. Rugo, MD, professor of medicine and director of breast oncology and clinical trials education at the University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, discusses the treatment of patients with metastatic breast cancer with chemotherapy.

Treating a patient with metastatic breast cancer with chemotherapy is controversial for a number of reasons, Rugo says. Several factors come into consideration in this setting: the choice of combination or single therapy, sequencing, treatment schedule, and length of treatment.

There is data that shows a better outcome for patients who continue on chemotherapy after response compared with those who go on a chemotherapy holiday. The caveat of this data is that many patients had hormone receptor-positive disease but did not receive hormone therapy during the chemotherapy holiday. The standard in the U.S. is to treat this group of patients with hormone therapy during a break.

For patients with triple-negative hormone-resistant disease, continued therapy was better for outcome than stopping and restarting.


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TitleExpiration DateCME Credits
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Community Practice Connections: Oncology Best Practice™ Targeting Cell Cycle Progression: The Latest Advances on CDK4/6 Inhibition in Metastatic Breast CancerOct 31, 20181.0
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