VISIT US IN CHICAGO JUNE 2-4 AT BOOTH 2073!

Dr. Saenger on Combining Targeted and Immune Agents

Yvonne M. Saenger, MD
Published: Wednesday, Jun 12, 2013

Yvonne M. Saenger, MD, Assistant Professor in Medicine and Dermatology, Hematology and Medical Oncology, Mount Sinai School of Medicine, discusses the idea of combining targeted and immune agents.

It is very attractive to combine these two types of agents, Saenger says, as targeted agents knock down the tumor burden; however, they generally do not produce long term responses. Additionally, when a large tumor is present, a patient is less likely to respond to immunotherapy, as the tumor is generally immunosuppressive.

The concept behind the phase II CA184-240 study in advanced melanoma is to hit the tumor with vemurafenib, a BRAF inhibitor, then administer ipilimumab, an CTLA-4-targeted immunotherapy. However, unfortunately, a previous trial using these drugs simultaneously demonstrated liver toxicity.

<<< View more from the 2013 ASCO Annual Meeting

Yvonne M. Saenger, MD, Assistant Professor in Medicine and Dermatology, Hematology and Medical Oncology, Mount Sinai School of Medicine, discusses the idea of combining targeted and immune agents.

It is very attractive to combine these two types of agents, Saenger says, as targeted agents knock down the tumor burden; however, they generally do not produce long term responses. Additionally, when a large tumor is present, a patient is less likely to respond to immunotherapy, as the tumor is generally immunosuppressive.

The concept behind the phase II CA184-240 study in advanced melanoma is to hit the tumor with vemurafenib, a BRAF inhibitor, then administer ipilimumab, an CTLA-4-targeted immunotherapy. However, unfortunately, a previous trial using these drugs simultaneously demonstrated liver toxicity.

<<< View more from the 2013 ASCO Annual Meeting




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 1st Annual School of Nursing Oncology™Oct 31, 20181.5
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
Publication Bottom Border
Border Publication
x