Dr. Sartor on Combining Radium-223 and Provenge

Oliver Sartor, MD
Published: Wednesday, Apr 25, 2012

Oliver Sartor, MD, medical director, Tulane Cancer Center, discusses a new trial concept that seeks to combine the radiopharmaceutical radium-223 chloride (Alpharadin) and the immunotherapy sipuleucel-T (Provenge), for men with castration-resistant prostate cancer.

Sartor explains the rationale behind this combination was based on the ability of radium-223 to release antigens, which makes the cancer cells more susceptible to immunotherapies, such as sipuleucel-T. The initial trial will likely be a small proof of concept study to gather evidence on the efficacy of the combination before it is tested in a larger population.

The companies that develop sipuleucel-T (Dendreon Corporation) and radium-223 (Bayer Pharma AG) have already agreed to participate in the trial.

Oliver Sartor, MD, medical director, Tulane Cancer Center, discusses a new trial concept that seeks to combine the radiopharmaceutical radium-223 chloride (Alpharadin) and the immunotherapy sipuleucel-T (Provenge), for men with castration-resistant prostate cancer.

Sartor explains the rationale behind this combination was based on the ability of radium-223 to release antigens, which makes the cancer cells more susceptible to immunotherapies, such as sipuleucel-T. The initial trial will likely be a small proof of concept study to gather evidence on the efficacy of the combination before it is tested in a larger population.

The companies that develop sipuleucel-T (Dendreon Corporation) and radium-223 (Bayer Pharma AG) have already agreed to participate in the trial.


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
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