Dr. Sartor on Patients in the ALSYMPCA Radium-223 Trial

Oliver Sartor, MD
Published: Tuesday, Dec 20, 2011

Oliver Sartor, MD, medical director, Tulane Cancer Center, describes the patients that were included in the phase III ALSYMPCA trial that examined radium-223 (Alpharadin), an experimental radiopharmaceutical, for symptomatic hormone refractory prostate cancer with skeletal metastases.

The inclusion criteria for the trial resulted in two groups of patients, those that had already received docetaxel and progressed and those deemed unfit to receive docetaxel.

The trial enrolled 922 men that were randomized 2:1 to receive either the current standard of care plus radium-223 or placebo. The experimental arm resulted in a 2.8-month median increase in progression-free survival and an increase of 5.2 months until the first skeletal related event.

Sartor notes that in the US only 55-60% of patients are deemed fit to receive docetaxel. These criteria resulted in a large number of patients being eligible to participate in the ALSYMPCA trial.

Oliver Sartor, MD, medical director, Tulane Cancer Center, describes the patients that were included in the phase III ALSYMPCA trial that examined radium-223 (Alpharadin), an experimental radiopharmaceutical, for symptomatic hormone refractory prostate cancer with skeletal metastases.

The inclusion criteria for the trial resulted in two groups of patients, those that had already received docetaxel and progressed and those deemed unfit to receive docetaxel.

The trial enrolled 922 men that were randomized 2:1 to receive either the current standard of care plus radium-223 or placebo. The experimental arm resulted in a 2.8-month median increase in progression-free survival and an increase of 5.2 months until the first skeletal related event.

Sartor notes that in the US only 55-60% of patients are deemed fit to receive docetaxel. These criteria resulted in a large number of patients being eligible to participate in the ALSYMPCA trial.


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
Publication Bottom Border
Border Publication
x