Dr. Scherber Discusses Ruxolitinib Failure in Myelofibrosis

Robyn M. Scherber, MD, MPH
Published: Friday, Nov 09, 2018



Robyn M. Scherber, MD, MPH, physician, The Mays Cancer Center, the newly named center of UT Health San Antonio MD Anderson Cancer Center, discusses ruxolitinib (Jakafi) failure in patients with myelofibrosis (MF).

Ruxolitinib is currently the only FDA-approved agent for the treatment of patients with MF, so ruxolitinib failure has become a larger issue. Although patients can stay on ruxolitinib for a long time with good response, Scherber says that after 2 or 3 years, response is often lost.

Discontinuation of ruxolitinib treatment is attributed to many factors, Scherber explains. One of the issues is that ruxolitinib failure is still poorly-defined, even though multiple clinical trials have tried to define it. The COMFORT-II, JAKARTA-2, SIMPLIFY-2, and the PAC203 trials addressed ruxolitinib duration. Ruxolitinib use ranged from 14 days to 28 days to 3 months before the treatment could be considered failed, Scherber explains.

Other factors of ruxolitinib failure include spleen size and disease progression.
SELECTED
LANGUAGE


Robyn M. Scherber, MD, MPH, physician, The Mays Cancer Center, the newly named center of UT Health San Antonio MD Anderson Cancer Center, discusses ruxolitinib (Jakafi) failure in patients with myelofibrosis (MF).

Ruxolitinib is currently the only FDA-approved agent for the treatment of patients with MF, so ruxolitinib failure has become a larger issue. Although patients can stay on ruxolitinib for a long time with good response, Scherber says that after 2 or 3 years, response is often lost.

Discontinuation of ruxolitinib treatment is attributed to many factors, Scherber explains. One of the issues is that ruxolitinib failure is still poorly-defined, even though multiple clinical trials have tried to define it. The COMFORT-II, JAKARTA-2, SIMPLIFY-2, and the PAC203 trials addressed ruxolitinib duration. Ruxolitinib use ranged from 14 days to 28 days to 3 months before the treatment could be considered failed, Scherber explains.

Other factors of ruxolitinib failure include spleen size and disease progression.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 22nd Annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas and MyelomaMay 30, 20192.0
Medical Crossfire®: Personalizing Care for Multiple Myeloma Patients: Current and Future Sequencing StrategiesMay 31, 20191.5
Publication Bottom Border
Border Publication
x