Dr. Sequist Discusses Adverse Events Associated With CO-1686

Lecia V. Sequist, MD
Published: Monday, Jun 16, 2014

Lecia V. Sequist, MD, medical oncologist, associate professor, Massachusetts General Hospital, Harvard Medical School, discusses adverse events (AEs) associated with CO-1686 for patients with non-small cell lung cancer (NSCLC).

CO-1686 was well tolerated in a phase I study presented at the 2014 ASCO Annual Meeting – AEs associated with CO-1686 were infrequent and mild. Nausea and hyperglycemia were most commonly observed, Sequist says, two AEs that are not commonly seen with other EGFR-inhibiting drugs.

Sequist says the question remains as to why these AEs are occurring. Physicians can adequately monitor patients that experience these AEs and stay away from severe episodes by reducing the dose of the study medicine and adding blood sugar-lowering medicine such as metformin.

Lecia V. Sequist, MD, medical oncologist, associate professor, Massachusetts General Hospital, Harvard Medical School, discusses adverse events (AEs) associated with CO-1686 for patients with non-small cell lung cancer (NSCLC).

CO-1686 was well tolerated in a phase I study presented at the 2014 ASCO Annual Meeting – AEs associated with CO-1686 were infrequent and mild. Nausea and hyperglycemia were most commonly observed, Sequist says, two AEs that are not commonly seen with other EGFR-inhibiting drugs.

Sequist says the question remains as to why these AEs are occurring. Physicians can adequately monitor patients that experience these AEs and stay away from severe episodes by reducing the dose of the study medicine and adding blood sugar-lowering medicine such as metformin.


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TitleExpiration DateCME Credits
Community Practice Connections™: 18th Annual International Lung Cancer Congress®Oct 31, 20181.5
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
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