ONCLIVE NEWS NETWORK: ON LOCATION WILL BE LIVE AT ESMO THIS WEEK - STAY TUNED FOR MORE INFORMATION!

Dr. Shulman on the CALGB 40101 Trial

Lawrence N. Shulman, MD
Published: Wednesday, Nov 13, 2013

Lawrence N. Shulman, MD, chief of staff, senior vice president for medical affairs, director, Center for Global Cancer Medicine, director, Department of Regional Strategy and Development, chief, Division of General Oncology, Dana-Farber Cancer Institute, discusses the results of the CALGB 40101 trial.

The trial, which compared the efficacy of adjuvant cyclophosphamide (AC) and doxorubicin versus paclitaxel, showed that paclitaxel is not equivalent to the AC combination, Shulman says.

Shulman says all statistical analyses showed that the AC combination is still the most effective treatment and that combination chemotherapy is essential. Unfortunately, Shulman says, AC is more toxic. Although the AC arm of the study had more occurrences of leukemia and cardiac death, it is still a better regimen overall.

Lawrence N. Shulman, MD, chief of staff, senior vice president for medical affairs, director, Center for Global Cancer Medicine, director, Department of Regional Strategy and Development, chief, Division of General Oncology, Dana-Farber Cancer Institute, discusses the results of the CALGB 40101 trial.

The trial, which compared the efficacy of adjuvant cyclophosphamide (AC) and doxorubicin versus paclitaxel, showed that paclitaxel is not equivalent to the AC combination, Shulman says.

Shulman says all statistical analyses showed that the AC combination is still the most effective treatment and that combination chemotherapy is essential. Unfortunately, Shulman says, AC is more toxic. Although the AC arm of the study had more occurrences of leukemia and cardiac death, it is still a better regimen overall.




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Community Practice Connections: Oncology Best Practice™ Targeting Cell Cycle Progression: The Latest Advances on CDK4/6 Inhibition in Metastatic Breast CancerOct 31, 20181.0
Publication Bottom Border
Border Publication
x