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Dr. Sieber on Managing Bone Health After ADT

Paul R. Sieber, MD
Published: Friday, May 25, 2012

Paul R. Sieber, MD, Urological Association of Lancaster, explains that the initial burst of activity following the introduction of androgen-deprivation therapy (ADT) is severe and may result in as much as a 10% loss in bone density. To add perspective, he notes that this degree of bone loss is 3 to 5 times what is lost during menopause in women.

Bone loss may continue in men as they continue to receive ADT, which makes managing and controlling bone health extremely important.

A number of agents are available to help manage bone health for prostate cancer patients. Sieber notes that the only agent with a direct FDA approval in prostate cancer is denosumab, a monoclonal antibody that binds to RANK ligand. Other agents, such as zoledronic acid (Zometa) and bisphosphonates are approved to treat bone metastases, but Sieber believes denosumab is superior to these agents.

Paul R. Sieber, MD, Urological Association of Lancaster, explains that the initial burst of activity following the introduction of androgen-deprivation therapy (ADT) is severe and may result in as much as a 10% loss in bone density. To add perspective, he notes that this degree of bone loss is 3 to 5 times what is lost during menopause in women.

Bone loss may continue in men as they continue to receive ADT, which makes managing and controlling bone health extremely important.

A number of agents are available to help manage bone health for prostate cancer patients. Sieber notes that the only agent with a direct FDA approval in prostate cancer is denosumab, a monoclonal antibody that binds to RANK ligand. Other agents, such as zoledronic acid (Zometa) and bisphosphonates are approved to treat bone metastases, but Sieber believes denosumab is superior to these agents.


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
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