Dr. Sledge Discusses Lasting Issues in Breast Cancer

George W. Sledge, Jr., MD
Published: Thursday, Apr 04, 2013

George W. Sledge, Jr, MD, Chief, Division of Oncology, Professor of Medicine, Stanford University School of Medicine, discusses the lasting issues in the treatment of breast cancer.

Though the mechanisms of resistance have been identified for several types of breast cancer, inhibiting the mechanism is difficult. In the case of a patient who is resistant to an aromatase inhibitor, everolimus (an mTOR inhibitor) allows resistance to be overcome, as mTOR is a common pathway. This issue is relatively straightforward, Sledge says, as the current knowledge of resistance just needs to be applied.

Estrogen receptor positive disease that lies dormant for 5-10 years still presents problems for physicians and researchers. Questions remain as to how dormant tumors can be identified and treated.

Finally, in the treatment of highly-aggressive disease such as triple-negative breast cancer, an obstacle exists as to what non-kinase-based approaches can be applied to achieve favorable results.
 
George W. Sledge, Jr, MD, Chief, Division of Oncology, Professor of Medicine, Stanford University School of Medicine, discusses the lasting issues in the treatment of breast cancer.

Though the mechanisms of resistance have been identified for several types of breast cancer, inhibiting the mechanism is difficult. In the case of a patient who is resistant to an aromatase inhibitor, everolimus (an mTOR inhibitor) allows resistance to be overcome, as mTOR is a common pathway. This issue is relatively straightforward, Sledge says, as the current knowledge of resistance just needs to be applied.

Estrogen receptor positive disease that lies dormant for 5-10 years still presents problems for physicians and researchers. Questions remain as to how dormant tumors can be identified and treated.

Finally, in the treatment of highly-aggressive disease such as triple-negative breast cancer, an obstacle exists as to what non-kinase-based approaches can be applied to achieve favorable results.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: CDK4/6 Inhibitors With the Experts: The Role of Emerging Agents for the Management of Metastatic Breast CancerMay 30, 20182.0
Medical Crossfire®: Clinical Updates on PARP Inhibition and its Evolving Use in the Treatment of CancersMay 30, 20181.5
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