Dr. Vokes on Nivolumab, Pembrolizumab Approvals in Head and Neck Cancer

Everett Vokes, MD
Published: Friday, Nov 11, 2016



Everett Vokes, MD, John E. Ultmann Professor of Medicine and Radiation Oncology, physician-in-chief, University of Chicago Medical Center, chair, Department of Medicine, University of Chicago Medicine, discusses the FDA approvals of the PD-L1 inhibitors nivolumab (Opdivo) and pembrolizumab (Keytruda) for the treatment of patients with head and neck cancer.
 
The FDA approved nivolumab for patients with metastatic or recurrent squamous cell carcinoma of the head and neck following progression on platinum-based therapy in November 2016. The approval is based on the CheckMate-141 study, in which the median overall survival with nivolumab was 7.5 months compared with 5.1 months with investigator's choice. The objective response rate was 13.3% with nivolumab and 5.8% for investigator's choice.


Everett Vokes, MD, John E. Ultmann Professor of Medicine and Radiation Oncology, physician-in-chief, University of Chicago Medical Center, chair, Department of Medicine, University of Chicago Medicine, discusses the FDA approvals of the PD-L1 inhibitors nivolumab (Opdivo) and pembrolizumab (Keytruda) for the treatment of patients with head and neck cancer.
 
The FDA approved nivolumab for patients with metastatic or recurrent squamous cell carcinoma of the head and neck following progression on platinum-based therapy in November 2016. The approval is based on the CheckMate-141 study, in which the median overall survival with nivolumab was 7.5 months compared with 5.1 months with investigator's choice. The objective response rate was 13.3% with nivolumab and 5.8% for investigator's choice.

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Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Evolving Applications of Immuno-Oncology Strategies: New Approaches, New Combinations, and New Ways to Care for Lung, Head and Neck, and Bladder CancersAug 31, 20182.0
Community Practice Connections™: New Directions in Advanced Cutaneous Squamous Cell Carcinoma: Emerging Evidence of ImmunotherapyAug 13, 20191.5
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