Dr. Wang on Triplet Vorinostat Regimen in Newly Diagnosed MCL

Michael Wang, MD
Published: Wednesday, Sep 25, 2019



Michael Wang, MD, professor in the Department of Lymphoma and Myeloma at The University of Texas MD Anderson Cancer Center, discusses data from a phase I/II study looking at the use a triplet regimen of vorinostat (Zolinza), cladribine (Mavenclad), and rituximab (Rituxan) in patients with newly diagnosed mantle cell lymphoma (MCL).

This single-arm study saw an overall response rate of 97% and complete response of 80% in the 39 patients with newly diagnosed MCL who participated, explains Wang. The results of the study are promising, says Wang, but require further investigation with a larger patient pool.

Vorinostat has been previously studied in non-Hodgkin lymphoma. Studies have shown that vorinostat as a single agent has lower a response rate at around 20% to 30%; however, these phase I/II data in newly diagnosed MCL demonstrates vorinostat works well in combination with cladribine and rituximab, concludes Wang.
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Michael Wang, MD, professor in the Department of Lymphoma and Myeloma at The University of Texas MD Anderson Cancer Center, discusses data from a phase I/II study looking at the use a triplet regimen of vorinostat (Zolinza), cladribine (Mavenclad), and rituximab (Rituxan) in patients with newly diagnosed mantle cell lymphoma (MCL).

This single-arm study saw an overall response rate of 97% and complete response of 80% in the 39 patients with newly diagnosed MCL who participated, explains Wang. The results of the study are promising, says Wang, but require further investigation with a larger patient pool.

Vorinostat has been previously studied in non-Hodgkin lymphoma. Studies have shown that vorinostat as a single agent has lower a response rate at around 20% to 30%; however, these phase I/II data in newly diagnosed MCL demonstrates vorinostat works well in combination with cladribine and rituximab, concludes Wang.



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