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Dr. Wilson on Long-term Data With Dabrafenib Plus Trametinib in Melanoma

Melissa A. Wilson, MD, PhD
Published: Thursday, Jul 27, 2017



Melissa A. Wilson, MD, PhD, an assistant professor of medicine at Perlmutter Cancer Center at NYU Langone Medical Center, discusses the long-term data with the combination of dabrafenib (Tafinlar) and trametinib (Mekinist) in patients with BRAF-mutant melanoma.

These 5-year overall survival data demonstrate that patients are staying on these treatments much longer than we initially anticipated, Wilson explains. Since the median progression-free survival was 11.4 months, to have 5-year data is important to show that there are patients who are still on these targeted therapies. Investigators' concerns were that patients would develop resistance, so it is showing that a select population still has continued benefit using these.

Brain metastases remains to be an unmet need still in the field of melanoma, as clinicians are seeing a number of patients actually recur with brain metastases.


Melissa A. Wilson, MD, PhD, an assistant professor of medicine at Perlmutter Cancer Center at NYU Langone Medical Center, discusses the long-term data with the combination of dabrafenib (Tafinlar) and trametinib (Mekinist) in patients with BRAF-mutant melanoma.

These 5-year overall survival data demonstrate that patients are staying on these treatments much longer than we initially anticipated, Wilson explains. Since the median progression-free survival was 11.4 months, to have 5-year data is important to show that there are patients who are still on these targeted therapies. Investigators' concerns were that patients would develop resistance, so it is showing that a select population still has continued benefit using these.

Brain metastases remains to be an unmet need still in the field of melanoma, as clinicians are seeing a number of patients actually recur with brain metastases.



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Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
35th Annual Chemotherapy Foundation Symposium: Innovative Cancer Therapy for Tomorrow® Clinical Vignette SeriesJan 31, 20192.0
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