Dr. Yu Discusses the Utility of GTx-758 in mCRPC

Evan Y. Yu, MD
Published: Monday, Feb 24, 2014

Evan Y. Yu, MD, associate professor, Department of Medicine, Division of Oncology, University of Washington School of Medicine, Seattle Cancer Care Alliance, discusses the utility of GTx-758 in metastatic castration-resistant prostate cancer (mCRPC).

GTx-758 is a selective estrogen receptor alpha agonist that potentially has multiple mechanisms of action, including upregulating sex hormone binding globulin (SHBG) and lowering free testosterone levels.

In this trial, patients with mCRPC being treated with leuprorelin (Lupron) with low testosterone received low-dose (125 mg per day) GTx-758. These patients saw upregulated SHBG and decreased free testosterone levels, which translated into PSA declines. Researchers plan to analyze GTx-758 at 250 mg per day.

Evan Y. Yu, MD, associate professor, Department of Medicine, Division of Oncology, University of Washington School of Medicine, Seattle Cancer Care Alliance, discusses the utility of GTx-758 in metastatic castration-resistant prostate cancer (mCRPC).

GTx-758 is a selective estrogen receptor alpha agonist that potentially has multiple mechanisms of action, including upregulating sex hormone binding globulin (SHBG) and lowering free testosterone levels.

In this trial, patients with mCRPC being treated with leuprorelin (Lupron) with low testosterone received low-dose (125 mg per day) GTx-758. These patients saw upregulated SHBG and decreased free testosterone levels, which translated into PSA declines. Researchers plan to analyze GTx-758 at 250 mg per day.




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
Community Practice Connections™: Precision Medicine for Community Oncologists: Assessing the Role of Tumor-Testing Technologies in Cancer CareNov 30, 20181.0
Publication Bottom Border
Border Publication
x