Dr. Zujewski Discusses Breast Cancer Drug Development

Jo Anne Zujewski, MD
Published: Thursday, Oct 03, 2013

Jo Anne Zujewski, MD, head, breast cancer therapeutics, cancer therapy evaluation program, National Cancer Institute (NCI), discusses the development of drugs to treat patients with breast cancer.

In the past, when breast cancer was considered a more homogenous disease, if a drug demonstrated a response rate of less that 10%, it was not thought to be worth developing. With the advent of actionable mutations and targeted therapeutics, there is now a need to determine which patients are exceptional responders. If an agent demonstrates a 1-10% response rate, it is worthwhile to develop for those patients who would see great benefit, Zujewski says.

The NCI is now focusing on exceptional responders and molecular identification, which requires nationwide laboratory testing to identify mutations and beneficial drugs that can be administered.

Jo Anne Zujewski, MD, head, breast cancer therapeutics, cancer therapy evaluation program, National Cancer Institute (NCI), discusses the development of drugs to treat patients with breast cancer.

In the past, when breast cancer was considered a more homogenous disease, if a drug demonstrated a response rate of less that 10%, it was not thought to be worth developing. With the advent of actionable mutations and targeted therapeutics, there is now a need to determine which patients are exceptional responders. If an agent demonstrates a 1-10% response rate, it is worthwhile to develop for those patients who would see great benefit, Zujewski says.

The NCI is now focusing on exceptional responders and molecular identification, which requires nationwide laboratory testing to identify mutations and beneficial drugs that can be administered.


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Clinical Interchange™: Moving Forward From the Status Quo for the Treatment of Soft Tissue Sarcoma: Key Questions and New Answers to Optimize OutcomesOct 31, 20182.0
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Publication Bottom Border
Border Publication
x