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Molecular Profiling in Colorectal Cancer

Panelists: Axel F. Grothey, MD , Mayo Clinic ; Daniel G. Haller, MD, University of Pennsylvania; Herbert I. Hurwitz, MD, Duke University Medical Center; J
Published: Wednesday, Jun 03, 2015

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The panel members agree that the majority of molecular tests, aside from those looking at microsatellite instability and RAS or RAF mutations, are not ready for primetime for patients with colorectal cancer (CRC). Right now, explains John P. Marshall, MD, 17-page reports with 150 references cataloguing a patients’ mutations are being generated. However, this information comes without evidence-based knowledge of what to do with it.
 
It's hoped that in 5 to 10 years that there will be standard genetic markers to use longitudinally, for example with circulating tumor cells, to help guide  treatment decisions, notes Axel Grothey, MD However, at this time actionable alterations are in short supply in CRC. The danger of acting on the information from pan-molecular testing is uncontrolled use of drugs without capturing information about the outcomes, Grothey adds.
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For High-Definition, Click
The panel members agree that the majority of molecular tests, aside from those looking at microsatellite instability and RAS or RAF mutations, are not ready for primetime for patients with colorectal cancer (CRC). Right now, explains John P. Marshall, MD, 17-page reports with 150 references cataloguing a patients’ mutations are being generated. However, this information comes without evidence-based knowledge of what to do with it.
 
It's hoped that in 5 to 10 years that there will be standard genetic markers to use longitudinally, for example with circulating tumor cells, to help guide  treatment decisions, notes Axel Grothey, MD However, at this time actionable alterations are in short supply in CRC. The danger of acting on the information from pan-molecular testing is uncontrolled use of drugs without capturing information about the outcomes, Grothey adds.
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