https://www.onclive.com/onclive-tv/dr-james-on-update-of-ibrutinib-for-chronic-lymphocytic-leukemia
Dr. James on Update of Ibrutinib for Chronic Lymphocytic Leukemia

Danelle James, MD, MAS



Danelle James, MD, MAS, head of Oncology at Pharmacyclics, assistant adjunct professor in the Division of Hematology-Oncology at the Chronic Lymphocytic Leukemia Research Consortium, discusses the RESONATE-2 study of ibrutinib (Imbruvica) versus chlorambucil through 5 years of treatment.

RESONATE-2 is a frontline phase III study comparing ibrutinib with chlorambucil for the treatment of patients 65 or older with active chronic lymphocytic leukemia (CLL). After 29 months of follow-up with these patients, there was continued tolerability with ibrutinib, with 77% of these 70-year-old patients continuing to take ibrutinib daily. About 90% of patients are now progression-free with over 2 years of follow-up.

It is suggested, explains James, that ibrutinib may be even more effective in these high-risk groups than with any traditional chemotherapeutic regimen.

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