New Chemotherapy Strategy Emerges in Ovarian Cancer

Anita T. Shaffer @Shaffer1
Published: Monday, Sep 24, 2012
Dr. Jonathan S. Berek

Jonathan S. Berek, MD, MMS
Professor and Director, Women’s Cancer Center, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA

A study evaluating first-line chemotherapy dosing strategies for treating patients with advanced epithelial ovarian cancer has delivered practice-changing findings, and ongoing trials are likely to provide further clarity on the comparative benefits of routes of administration, according to Jonathan S. Berek, MD, MMS.

Key Statistics in JGOG 3016 Trial, at 6.4 Years’ Follow-Up1

Treatment Patients (No) Median PFS Median OS
Dose-Dense 312 28.2 mo Not reached
Conventional 319 17.5 mo 62.2 mo
P value   .0037 .039

PFS indicates progression-free survival; OS, overall survival.

A subgroup analysis indicated that patients with clear-cell and mucinous carcinomas, who made up 15% to 17% of patients, did not show a statistically significant advantage with either treatment strategy. More than 80% of the patients in each arm had serous adenocarcinomas and other types.

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