Sorting Through the Alphabet Soup of Evolving Treatments in CLL

Christina T. Loguidice
Published: Tuesday, May 15, 2018
Dr. William G. Wierda

William G. Wierda, MD, PhD
The rapid introduction of new therapies for chronic lymphocytic leukemia (CLL) during the past several years has remade the treatment paradigm, presenting clinicians with a challenging array of options at a time when further advancements are in the works.

“It’s a very exciting time because of all the novel therapies, and I think now our goal is to develop new generations of therapy, trying to minimize the toxicity with the oral agents, and to improve upon what we have available by doing the novel–novel combination or novel– conventional combinations to achieve a really deep response,” said Shuo Ma, MD, PhD. She noted that minimal residual disease (MRD) negativity is now achievable and will hopefully translate to a very long progression- free survival (PFS) for patients.

The CLL Landscape

CLL is the most prevalent adult leukemia in Western countries, predominantly affecting middle-aged and elderly adults (>90% diagnosed at ≥55 years).1 In the United States in 2018, more than 20,000 new CLL cases are expected to be diagnosed, with approximately 4500 people dying from the disease.2

In 2016, the FDA approved another small-molecule inhibitor, venetoclax (Venclexta), for patients with CLL and 17p deletion (del[17p]).

Novel Combinations in CLL

Currently, in the frontline and relapsed/refractory setting, most combinations recommended by the National Comprehensive Cancer Network include rituximab (Rituxan). Ibrutinib plus bendamustine and rituximab, idelalisib plus rituximab, and venetoclax plus rituximab are the preferred regimens in the relapsed/refractory setting, including for high-risk patients.1 Numerous clinical trials are currently underway that are examining a variety of novel–novel combinations.
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