Investigators Express Confidence in a Novel TKI That Targets Rare Sarcomas

Brittany Lovely
Published: Wednesday, Jun 26, 2019
Jonathan C. Trent, MD, PhD

Jonathan C. Trent, MD, PhD

Anlotinib, a novel tyrosine kinase inhibitor capable of mounting a multipronged attack against oncogenic processes, is being tested in rare soft tissue sarcoma subtypes where patients have limited therapeutic options.

The phase III APROMISS trial (NCT03016819) is evaluating the safety and efficacy of anlotinib monotherapy versus dacarbazine in patients with metastatic or advanced alveolar soft part sarcoma (ASPS), leiomyosarcoma (LMS), and synovial sarcoma (SS).

These malignancies are among many sarcoma subtypes thought to depend upon signaling through VEGFR (vascular endothelial growth factor receptor), PDGFR (platelet-derived growth factor receptor) FGFR (fibroblast growth factor receptor) and possibly KIT, Jonathan C. Trent, MD, PhD, said in an interview with OncologyLive®. “Inhibition of these pathways may be able to induce tumor cell death directly through inhibition of PDGFR as well as FGFR, but also indirectly through the antivascular effects of inhibition of VEGFR,” Trent said. Anlotinib targets multiple proteins in these cell signaling networks. Trent is a professor and associate director for clinical research at the University of Miami Sylvester Comprehensive Cancer Center in Florida.

In APROMISS, patients with ASPS will receive anlotinib at a dose of 12 mg once daily in 21-day cycles (14 days on treatment, 7 days off treatment) until disease progression. Enrolled patients with metastatic or advanced LMS or SS will be randomized 2:1 to receive anlotinib at the same dosage or intravenous dacarbazine until disease progression (Figure).1

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