Investigators Link Novel Biomarker to Therapy in DLBCL Trial

Investigators are exploring the novel genetic biomarker Denovo Genomic Marker 1 (DGM1) as a potential predictor of benefit from the experimental agent enzastaurin in treatment-naïve patients with high-risk diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma subtype.¹

Neither lenalidomide nor ibrutinib added to R-CHOP in either study extended survival: ROBUST did not meet its primary end point of progression-free survival, and PHOENIX missed its primary end point of event-free survival.4,5 However, positive trends with R2-CHOP were noted in subgroups with high-risk and advanced stage DLBCL.

Figure. Enzastaurin with R-CHOP in DGM1-Positive DLBCL

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