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Immunotherapy Research in Oncology Focuses on Resistance

Gina Battaglia, PhD
Published: Thursday, Dec 19, 2019
Julie R. Brahmer, MD

Julie R. Brahmer, MD
Research into the mechanisms that promote resistance to immune checkpoint blockade therapies suggests the need for new strategies for patients with immunorefractory disease. Despite increased attention in recent years to tumor cell-extrinsic mechanisms and the roles that cells in the tumor microenvironment play, there are still many unanswered questions surrounding the causes of resistance, according to Julie R. Brahmer, MD, director of the thoracic oncology program and professor of oncology at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University in Baltimore, MD. “Clarifying mechanisms of resistance to immune checkpoint inhibitors will help with development of strategies for patients who do not respond to or develop aquired resistance to immunotherapy,” Brahmer said in an interview with OncologyLive®.
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