NCCN Guidelines Reflect Recent FDA Approvals for Hematologic Malignancies

Published: Wednesday, Feb 13, 2019
 Meletios A. Dimopoulos, MD

Meletios A. Dimopoulos, MD
New options for patients with hematologic malignancies stemming from recent FDA approvals are making an impact on treatment strategies recommended in the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology.

Waldenström Macroglobulinemia

The FDA recently approved ibrutinib (Imbruvica) plus rituximab (Rituxan) for the treatment of Waldenström macroglobulinemia (WM), or lymphoplasmacytic lymphoma, a rare form of B-cell lymphoma that is characterized by bone marrow infiltration by lymphoplasmacytic cells.2 The approval expands the label of ibrutinib in WM from its currently approved use as monotherapy to include the first nonchemotherapy combination in this malignancy.
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