AXL Kinase Becomes a Therapeutic Target in Its Own Right

Jane De Lartigue, PhD
Published: Tuesday, Mar 17, 2020
Despite being implicated across the spectrum of cancer hallmarks, aberrant AXL signaling is just starting to emerge as a distinct anticancer target, with a growing focus on specific inhibitors as well as alternative novel drug designs.

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A Unique Receptor Family

Alterations in kinase genes are among the most common oncogenic events in cancer and thus present logical drug targets; approximately a quarter of ongoing drug development efforts involve kinase inhibitors.8

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