Photo by ©AACR/Phil McCarten 2012
Ignacio Melero, MD, PhD
Three-fourths of patients with advanced hepatocellular carcinoma (HCC) associated with hepatitis C (HCV) infection achieved disease control with antibody therapy directed at a T-cell antigen, according to data from a preliminary clinical study presented at the 2012 AACR Annual Meeting.
A disease control rate in excess of 75% and a time to progression longer than 4 months suggest that tremelimumab could be active against hepatocellular carcinoma.” –Ignacio Melero, MD, PhD
Tremelimumab has demonstrated activity in several preclinical cancer models and has produced evidence of efficacy in melanoma. The agent had not been tested in HCC, nor had its antiviral activity been evaluated. However, Melero and colleagues had evidence of lymphocyte invasion in HCC and CTLA-4 expression in HCV, providing a rationale for clinical investigation of tremelimumab in HCV-associated HCC.
Melero I, Sangro B, Riezu-Boj JI, et al. Antiviral and antitumoral effects of the anti-CTLA4 agent tremelimumab in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C virus (HCV) infection: Results from a phase II clinical trial. Presented at the American Association for Cancer Research; March 31-April 4, 2012; Chicago, IL. Abstract 4387.