Maurie Markman, MD
The debate continues: How can a new antineoplastic agent be approved for marketing if it has not been demonstrated in at least 1 well-designed phase III randomized clinical trial to offer a statistically significantly overall survival (OS) advantage? Is it possible to disagree with the simple logic that this endpoint must be the major aim of all antineoplastic agents, to improve the survival of patients receiving the drug? After all, isn’t this what patients want to achieve, the greatest possible duration of survival?
Further, the thinking goes, with the staggering increases in the costs of therapeutic cancer drugs, a new agent should simply not be permitted to enter the commercial market unless it has been documented to improve survival. The economist may rationally argue that merely prolonging the time until the next adverse event develops or an imaging study reveals an increase in the size of an existing small tumor mass should not be a sufficient reason for a manufacturer to be permitted to charge patients and third-party payers $10,000 to $15,000 or more per month for a new drug.
I don’t disagree with the premise that improving survival is a critically relevant aim of antineoplastic drug therapy, but I do vigorously challenge the notion that this highly meaningful outcome can be supported by the OS endpoint of phase III randomized trials. Although it is not difficult to provide strong evidence to support this conclusion, in this brief commentary, I can highlight only a few clinically relevant examples.
We begin with the recently reported experience associated with ALK
mutation–positive non–small cell lung cancer and the delivery of crizotinib (Xalkori), a highly active agent that was approved for this indication in 2014.1
Previously published data from an international, multi center, phase II randomized trial revealed the progression-free survival (PFS) superiority of this agent to standard-of-care chemotherapy (pemetrexed [Alimta] with cisplatin or carboplatin) in the patient population whose cancer exhibited this relatively uncommon (2%-6% incidence) molecular abnormality (HR, 0.45; median PFS, 10.9 vs 7.0 months).2
The objective response rate was also greater following treatment with this targeted therapeutic agent. However, in the final OS analysis (median follow-up, 46 months) published 4 years after the FDA approval, there was no statistically significant difference between the 2 therapeutic strategies (HR, 0.760; P
= .0978). Survival at 4 years was 56.6% in patients randomized to the crizotinib arm of the trial and 49.1% in individuals receiving chemotherapy.2
It is significant that 75% of the individuals (128 of 171 patients) randomized to initial treatment with chemotherapy subsequently crossed over to receive the targeted therapeutic agent following disease progression.2
The data suggest a substantial proportion of these individuals achieved clinical benefit resulting in an improvement in their ultimate survival, which made it impossible to document a statistically significant improvement in OS based on the initial treatment regimen assignment. The bottom line is that both patient populations experienced a survival benefit because most individuals within the 2 groups ultimately received crizotinib (either as first-line or later therapy).
Perhaps the most striking example of a trial-arm crossover that negated the utility of an antineoplastic investigative study for demonstrating a definitive statistically significant OS outcome can be found in the landmark phase III randomized trial in chronic-phase chronic myelogenous leukemia. This compared imatinib (Gleevec) with the standard of care at that time of cytarabine plus interferon-α.3,4
Crossover to imatinib from the less-effective (and more toxic) standard-of-care study arm occurred relatively quickly (64% of patients after a median duration of 9 months of treatment), which made the study incapable of demonstrating an improvement in OS for the imatinib trial arm.3,4
Subsequently conducted alternative statistical analyses and population-based data have clearly documented highly impressive survival benefits associated with the use of imatinib,3-5
but for the reasons stated, these were not observed within the confines of the formal intention-to-treat analysis of the randomized phase III trial.