Andrew J. Armstrong, MD
Seeking to explore an apparent synergy between agents, investigators are evaluating the PARP inhibitor olaparib (Lynparza) in combination with the hormone blocker abiraterone (Zytiga) in men with metastatic castration-resistant prostate cancer (mCRPC) who have received no prior cytotoxic chemotherapy or new hormonal agents. The multicenter phase III PROpel study (NCT03732820) will enroll approximately 720 patients globally and randomize them to receive olaparib with abiraterone or placebo plus abiraterone.
Figure. Olaparib Plus Abiraterone as Frontline mCRPC Therapy1
Full data are expected to be presented at an umpcoming medical meeting.
... to read the full story