Recent research from Dr. Fine and others has found that glioblastoma tumors—the most malignant gliomas—typically harbor genetic mutations that differ from patient to patient and offer no obvious common target for therapies. Part of Dr. Fine’s organoid-based research will therefore involve the development of personalized brain-cancer models using cerebral organoids derived from the cells of patients, which may lead to the development of precision medicine treatment strategies. “We’ll be able to make hundreds of brain organoids for any given patient and use them to screen for drugs that can shrink that patient’s tumor,” he said.
The NIH Director’s Pioneer Award is supported by the National Institutes of Health under Award Number 1DP1CA228040. The content of this press release is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.Weill Cornell Medicine
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