Ruth Lupu, PhD
By targeting the HER2 protein’s ability to transform cells, therapies such as trastuzumab (Herceptin) and pertuzumab (Perjeta) have significantly extended the survival of women with HER2-positive breast cancer. However, major treatment challenges still remain for this breast cancer subtype, according to Ruth Lupu, PhD, professor of Laboratory Medicine and Pathology at Mayo Clinic.
Menendez JA, Schroeder B, Peirce SK, et al. Blockade of a key region in the extracellular domain inhibits HER2 dimerization and signaling [published online April 17, 2015]. J Natl Cancer Inst. doi: 10.1093/JNCI/djv090.
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