Thomas Kipps, MD, PhD
High-risk patients with chronic lymphocytic leukemia (CLL) who have an 11q deletion—said to be an adverse predictor of poor outcomes—can have durable responses when treated with the BTK inhibitor ibrutinib (Imbruvica), according to pooled analyses of results from the phase III HELIOS, RESONATE, and RESONATE-2 studies presented at the 17th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting.
, Kipps explained the details of the integrated analysis from the iwCLL meeting, his ongoing research with ROR1 as a target in CLL, and pivotal combination studies being conducted with ibrutinib.
OncLive: Please discuss your research presented at the iwCLL conference on outcomes of ibrutinib-treated patients with CLL/small lymphocytic leukemia with high-risk prognostic factors.
We were involved in these clinical trials, but I was the senior author of the trial that we put together of patients being randomized to treatment with ibrutinib versus chlorambucil. These were patients older than age 65 and patients who had some medical comorbidities. Particularly, in Europe, chlorambucil is not a bad choice by European standards, although it is less frequently used in the United States. We had the trial where patients were randomized to receive ibrutinib versus chlorambucil as part of the RESONATE-2 study, and what we observed in that was that patients treated with ibrutinib fared better than patients treated with chlorambucil. There was a significant improvement not only in progression-free survival, but also in overall survival despite the fact there was some crossover. There seemed to be a distinct advantage for patients treated with ibrutinib.
... to read the full story