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Bevacizumab Biosimilar Demonstrates Similar Response Rate, Survival as European Originator

Wayne Kuznar
Published: Tuesday, Jun 05, 2018

Mark A. Socinski, MD

Mark A. Socinski, MD
The bevacizumab (Avastin) biosimilar PF-06439535 demonstrated similarity to the European Union (EU) bevacizumab reference product for overall response rate (ORR), with similar pharmacokinetic and immunogenicity profiles for patients with advanced non-squamous non-small cell lung cancer (NSCLC), according to results presented at the 2018 ASCO Annual Meeting.

Data from an ongoing double-blind, randomized, global clinical trial (NCT02364999) showed ORR rates of 45.3% (95% CI, 40.01-50.57) for firstline PF-06439535 combination with paclitaxel and carboplatin compared with 44.6% (95% CI, 39.40-49.89) for bevacizumab-EU at 19 weeks (confirmed by week 25) in the intent-to-treat population, the primary endpoint of the trial.

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TitleExpiration DateCME Credits
Medical Crossfire®: Addressing Uncertainties in Oncology BiosimilarsApr 30, 20201.5
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