Sandra Horning, MD
Atezolizumab (Tecentriq) improved survival compared with docetaxel in patients with advanced non–small cell lung cancer (NSCLC) following the failure of platinum-based chemotherapy, according to findings from the phase III OAK trial.
The survival benefit was observed regardless of PD-L1 status, Genentech, the manufacturer of the PD-L1 inhibitor, reported in a statement. The company also noted that the safety profile for atezolizumab in the OAK trial was consistent with previously reported adverse event (AE) data for the drug. Genentech plans to present the complete results from the study at a medical meeting this year.
“These results add to the growing body of evidence that supports the role of Tecentriq as a potential new treatment for specific types of advanced NSCLC,” Sandra Horning, MD, chief medical officer and head of Global Product Development at Genentech, said in a statement. “This is very encouraging news for people living with this disease because lung cancer is the leading cause of cancer deaths around the world. We hope to bring this treatment option to patients as soon as possible.”
The international, open-label randomized phase III OAK trial included 1225 patients with locally advanced or metastatic NSCLC who progressed during or after platinum-containing chemotherapy. Patients were randomized in a 1:1 ratio to 75 mg/m2
of intravenous docetaxel or 1200 mg of intravenous atezolizumab every 3 weeks.
The coprimary endpoints of the trial were overall survival (OS) in the entire study population and in a PD-L1–defined subgroup. Secondary endpoints included progression-free survival (PFS), objective response rate (ORR), and duration of response. The primary efficacy assessment included only the initial 850 randomized patients, and the secondary efficacy analysis will include data from all 1225 randomized patients.
In April 2016, the FDA granted a priority review to atezolizumab for the treatment of patients with locally advanced or metastatic NSCLC who express PD-L1 and have progressed after a platinum-containing regimen. Under the expedited priority program, the FDA will issue a final decision on approval by October 19, 2016.
The priority review is based on data from multiple clinical trials, including the phase II BIRCH study, in which responses were observed in up to 27% (P
= .0001) of previously treated patients with NSCLC who had the highest levels of PD-L1 expression.1
The open-label, single-arm phase II BIRCH study enrolled 667 patients with stage IIIB/IV or recurrent NSCLC who did not have active CNS metastases. Patient characteristics were balanced across cohorts; the median age was 64 years, 35% were ECOG PS 0, 28% had squamous NSCLC, and 17% of patients were never-smokers. EGFR
mutations were identified in 327 and 177 patients overall, respectively.
All patients had disease that expressed PD-L1 as measured on tumor cells (TC) and tumor-infiltrating immune cells (IC) by Roche’s investigational IHC test. An IHC score of TC2/3 or IC2/3 was the inclusion criteria established by the trial design.
Atezolizumab was administered at 1200 mg IV at 3-week intervals as frontline therapy to 142 patients (cohort 1), as second-line to 271 patients who had progressed after 1 prior platinum therapy (cohort 2), and to 254 patients who had undergone 2 or more prior chemotherapy regimens (cohort 3).
Overall response rate was the primary endpoint, with secondary outcome measures including duration of response, PFS, OS, and safety.
Among the 659 evaluable patients, the median treatment duration across all cohorts was 4.2 months (range, 0-15). The ORR in cohort 1 was 19% and 17% in cohorts 2 and 3 in patients with TC2/3 or IC2/3 expression. Stronger response was seen in patients with higher expression; ORR rates were 26%, 24%, and 27% in cohorts 1, 2, and 3 in patients with PD-L1 expression of level TC3 or IC3.
At a median follow-up of 8.8, 7.9, and 8.6 months, median OS was 14 months, not reached (NR), and NR, across cohorts 1, 2, and 3, respectively. Six-month OS was achieved by 82%, 76%, and 71% of patients TC2/3 or IC2/3 expression levels in cohorts 1, 2, and 3, respectively, and by 79%, 80%, and 75% of patients in cohorts 1, 2, and 3 having TC3 or IC3 expression levels.
Six-month PFS rates were 46%, 29%, and 31% at the PD-L1 expression level of TC2/3 and IC2/3 and 48%, 34%, and 39% in patients with TC3 or IC3 expression levels in cohorts 1, 2, and 3, respectively.
The safety data for atezolizumab in BIRCH were similar to those observed in other trials. The most commonly reported AEs were fatigue (18%) and nausea (10%). Grade 3/4 treatment-related AEs occurred in 11% of patients overall and 6% of patients discontinued therapy due to a treatment-related AE. All-cause grade 3/4 AEs occurred in 38% of patients.