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Byrd Highlights Ibrutinib's Continued Progress in CLL

Gina Columbus @ginacolumbusonc
Published: Monday, Jun 12, 2017

John C. Byrd, MD

John C. Byrd, MD

A 4-year follow-up of the RESONATE study, comparing the BTK inhibitor ibrutinib (Imbruvica) to ofatumumab (Arzerra), continues to demonstrate ibrutinib’s benefit in patients with chronic lymphocytic leukemia (CLL) who had at least 1 prior therapy.

during the 2017 ASCO Annual Meeting, Byrd shed light on the game-changing efficacy of ibrutinib in CLL.

OncLive: Can you discusse the updated findings from the RESONATE study presented at this meeting?

Byrd: The RESONATE study is the first randomized phase III study that reported out the first-in-class irreversible inhibitor ibrutinib. This was a randomized trial that compared ibrutinib in second or greater line to ofatumumab, a standard of care for patients with CLL at that time. Patients were randomized to 1 or the other therapy; at the initial part of the trial, there was not a crossover. After it was clear that ibrutinib had significant activity, loss of equipoise existed for the control, and a crossover was allowed. What was presented at the 2017 ASCO Annual Meeting was long-term follow-up—a median of 45 months for most patients and, for some patients, out as far as 4.5 years. 
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