Gisela Schwab, MD
Cabozantinib (Cabometyx) improved overall survival (OS) versus placebo in patients with advanced hepatocellular carcinoma (HCC) who have previously received sorafenib (Nexavar), meeting the primary endpoint of the phase III CELESTIAL trial.
The most common grade 3/4 adverse events were diarrhea (20%), hand-foot syndrome (15%), and thrombocytopenia (15%). Nearly 2 in 3 patients (59%) required dose reductions.
Kelley RK, Verslype C, Cohn AL, et al. Cabozantinib in hepatocellular carcinoma: results of a phase 2 placebo-controlled randomized discontinuation study. Ann Oncol. 2017;28(3):528-534. doi: 10.1093/annonc/mdw651.
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