Keith Stewart, MB, ChB
The combination of carfilzomib (Kyprolis), lenalidomide (Revlimid), and dexamethasone (KRd) extended overall survival (OS) for patients with relapsed or refractory multiple myeloma by nearly 8 months compared with lenalidomide and dexamethasone alone (Rd) in results from the phase III ASPIRE trial published in the Journal of Clinical Oncology.
The findings, which were reported at the 2017 ASH Annual Meeting, showed that the median OS was 48.3 months for patients assigned to KRd compared with 40.4 months for those assigned to Rd (HR, 0.79; 95% CI, 0.67-0.95; P
= .0045). KRd was associated with an 11.4-month survival advantage in patients at first relapse (47.3 vs 35.9 months; HR, 0.81, 95% CI, 0.62-1.06).
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