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CDK4/6 Inhibitors Showing Survival Gains in Metastatic HR+ Breast Cancer

Caroline Seymour
Published: Tuesday, Aug 06, 2019

Payal D. Shah, MD, an assistant professor of medicine at Perelman School of Medicine, Hospital of the University of Pennsylvania

Payal D. Shah, MD

There are now 3 FDA-approved CDK4/6 inhibitors from which to choose from for patients with metastatic hormone receptor (HR)–positive, HER2-negative breast cancer, all showing an extension in progression-free survival (PFS) and objective response rates (ORR) in the first- and second-line settings. Now, they are demonstrating improvements in overall survival (OS) in select populations as well.
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