Michel Attal, MD
Consolidation therapy with lenalidomide, bortezomib, and dexamethasone (RVD), when used in conjunction with stem cell transplantation, extended progression-free survival (PFS) compared with RVD alone in patients with multiple myeloma.1
However, in results from Intergroupe Francophone du Myélome (IFM) 2009 trial published in New England Journal of Medicine
, researchers found that overall survival (OS) was similar for both treatments.
After the induction phase, all the patients underwent stem-cell mobilization with cyclophosphamide and granulocyte colony-stimulating factor.
During the consolidation phase, patients were randomly assigned to 5 cycles of RVD with a reduced daily dose of 10 mg of dexamethasone (n = 350) or 200 mg/m2 of IV melphalan plus autologous stem-cell transplantation (ASCT) followed by 2 cycles of RVD with 10 mg of dexamethasone (n = 350).
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