Howard I. Scher, MD
An analysis of results from 5 clinical trials showed that circulating tumor cell (CTC) conversion and CTC value ≥ 1 at baseline (CTC0) were superior predictors of overall survival (OS) than PSA in men with metastatic castration-resistant prostate cancer (mCRPC).
Overall, 75% of eligible patients were evaluable for the CTC0 endpoint compared with 51% for the CTC conversion endpoint. In these 5 studies, the relative increase in the percentage of patients evaluable for the CTC0 endpoint compared with CTC conversion ranged from 29% to 71%. The greatest proportional increase occurred among chemotherapy-naïve patients and the least difference occurred among those who had been exposed to at least 2 prior treatments.
Heller G, McCormack R, Kheoh T, et al. Circulating tumor cell number as a response measure of prolonged survival for metastatic castration-resistant prostate cancer: comparison with prostate-specific antigen across five randomized phase III clinical trials [published online December 22, 2017]. J Clin Oncol doi: 10.1200/JCO.2017.75.2998.
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